The study, published in the International Journal of Biological Macromolecules, describes a silk-derived material that speeds up skin repair in animal models while reducing inflammation and supporting new tissue growth.  

The hydrogel, known as PATS, combines silk sericin (a protein extracted from silkworm cocoons) with tetrakis (hydroxymethyl) phosphonium sulfate (THPS), a biodegradable antibacterial compound. These components are bonded within a polyvinyl alcohol and agarose matrix, creating a strong and stable three-dimensional structure. THPS provides antimicrobial activity against Escherichia coli and Staphylococcus aureus, while silk sericin delivers antioxidant protection and promotes cell proliferation.  

In tests on rats with full-thickness skin wounds, the hydrogel achieved a healing rate of nearly 86 per cent after 14 days. The treatment reduced inflammation and enhanced both angiogenesis and follicle formation, indicating robust tissue regeneration. Laboratory analyses also showed the material’s ability to neutralise free radicals – protecting cells from oxidative stress that can otherwise delay healing.  

The authors say the new material offers a sustainable alternative to antibiotic-loaded or metal-based dressings, combining infection control with biocompatibility. They note that the silk by-product used to create the hydrogel could also help reduce industrial waste from the silk-reeling industry.