The study rigorously tested the bioactive vesicles according to international safety standards.  

The ADVs demonstrated an excellent safety profile, showing no genotoxic, cytotoxic, corrosive, or sensitisation effects in standard assays – including the Ames test and OECD-compliant skin and corneal models.  

In functional assessments over 60 days, the formulation significantly reduced skin redness (p < 0.05) and improved wrinkle length, volume, and roughness – highlighting its soothing and antiageing potential.  

For regenerative aesthetic medicine, these findings support the idea that plant-derived vesicles may offer a novel, biocompatible alternative to traditional bioactives.

ADVs could be incorporated into post-procedural care to reduce inflammation and accelerate visible skin rejuvenation – without ethical or regulatory concerns tied to human or animal-derived ingredients.