PRF –  a fibrin matrix rich in platelets, growth factors, and cytokines – has long been used in regenerative medicine to promote tissue repair. The review, published in October 2025, explores how integrating PRF with polymers such as chitosan, collagen, hyaluronic acid, polycaprolactone (PCL), and PLGA enhances its stability and therapeutic performance. These polymer scaffolds help regulate the release of PRF’s bioactive molecules, sustaining cell recruitment, angiogenesis, and extracellular matrix formation over time.  

Researchers emphasise that the physicochemical properties of the composite, including cross-linking density and degradation rate, are key to creating an optimal wound environment. Evidence from preclinical and early clinical studies indicates that PRF-polymer systems accelerate the closure of chronic and acute wounds while helping to reduce inflammation and infection risk.  

The authors also note ongoing challenges in standardising preparation methods, scaling up production, and ensuring long-term stability. However, advances in smart and stimuli-responsive polymers – capable of releasing bioactive factors in response to temperature, pH, or inflammation – are expected to drive further progress.  

According to the review, PRF-polymer composites represent a “transformative approach” in regenerative wound care, uniting the biological potency of blood-derived growth factors with the structural precision of biomaterial design.