The study enrolled 30 adult patients, with 29 completing the full protocol. Participants underwent three intradermal treatment sessions at monthly intervals, receiving a combination of autologous PRP and hyaluronic acid. Clinical outcomes were assessed over a 32-week follow-up period using objective instrumental measurements alongside clinical and patient-reported assessments.  

Results showed statistically significant improvements in skin firmness, with Cutometer measurements demonstrating a 54% improvement from baseline at three months and a 65% improvement at six months following the final treatment (p < 0.0001). Skin hydration also improved significantly and remained elevated throughout follow-up (p < 0.01).  

Additional improvements were observed in melanin and erythema indices, indicating reductions in pigmentation and redness at six months (p < 0.01). Sebum levels decreased significantly after the second treatment session and remained lower at three months post-treatment (p < 0.05). Skin elasticity showed a statistically significant early improvement at one month post-treatment (p = 0.0217), although this effect was not sustained at later time points. No statistically significant changes were reported for skin texture, wrinkle depth or overall brightness.  

From a safety perspective, the combination treatment was well tolerated. Reported adverse effects were mild and transient, limited mainly to local injection-site reactions such as erythema, swelling or bruising, with no serious adverse events observed.  

The authors note limitations including the modest sample size, absence of a control group and relatively short follow-up, and emphasise the need for larger, controlled studies to further define optimal protocols and durability of effect.