Some of these compounds have shown potential in reducing signs of skin ageing at the cellular level.  

The research team, led by scientists from the University of California, Berkeley, and UCLA, used a combination of mass spectrometry, isotope labeling, and genome analysis to identify and characterise a total of 12 indole-based compounds. Six of them are newly reported.  

Testing on human dermal fibroblasts showed that several of these metabolites reduced reactive oxygen species (ROS), inflammatory markers, and matrix metalloproteinase-1 (MMP-1), which is involved in collagen breakdown. These effects suggest possible applications in skin health.  

“These data indicate that indole-functionalised natural products from P. sanguinis may serve as leads for the development of anti-skin-ageing agents,” the authors write.  

This study highlights blood-associated microbes as a potential source of bioactive small molecules, particularly those that might be relevant in dermatological or therapeutic contexts. However, further research is needed to evaluate their safety, efficacy, and mechanisms of action in more complex models.