Published in Clinical, Cosmetic and Investigational Dermatology, the review describes how exosomes contribute to immune signalling, inflammation and skin cell communication in psoriasis. The authors suggest these extracellular vesicles play a central role in disease progression by transporting proteins, lipids and genetic material that influence inflammatory pathways. 

The review also explores the therapeutic potential of engineered and stem cell-derived exosomes, which have shown anti-inflammatory and tissue-repair effects in preclinical studies. In addition, exosomes may offer a novel platform for targeted drug delivery, potentially improving treatment efficacy while reducing systemic side effects. 

While the findings highlight the promise of exosome-based approaches for psoriasis, the authors emphasise that further research is needed to standardise exosome isolation and manufacturing methods, establish safety and efficacy, and confirm their clinical value in large-scale human studies.