A narrative review published in Aesthetic Surgery Journal has compared exosome- and hybrosome-based therapies in regenerative medicine, skin ageing and aesthetic procedures.  

The authors describe exosomes as nanoscale extracellular vesicles involved in intercellular communication, inflammation modulation, angiogenesis and extracellular matrix remodelling. However, they note that clinical use remains limited by challenges around stability, bioavailability, consistency and delivery. 

Hybrosomes are described as engineered hybrid vesicles that combine exosomal membranes with liposomal structures. According to the review, this design may help protect bioactive cargo, improve vesicle stability and prolong regenerative activity. 

The paper discusses potential relevance for skin regeneration, wound healing, skin ageing and perioperative aesthetic protocols, including pre-treatment optimisation and post-procedure recovery. 

However, the authors emphasise that further long-term clinical studies and standardised production protocols are needed before hybrosome-based therapies can be considered reliable, scalable interventions in regenerative and aesthetic medicine.