The study included 20 patients aged 40 to 80 years who were treated with Ultra V® UltraCol 200, a liquid PDO collagen biostimulator, mixed with organic silicon. Injections were performed using the facial adipostructuring technique, a vector-based approach designed to reorganise facial adipose compartments and improve tissue support. 

According to the authors, clinical evaluation demonstrated improvements in facial tridimensionality, contour definition and volumetric projection. Reductions in nasolabial fold depth and improved positioning of the malar region were also observed following treatment. 

The paper discusses PDO microspheres as collagen biostimulators capable of promoting neocollagenesis through a controlled inflammatory response, while organic silicon was proposed as a potential enhancer of regenerative activity. 

However, the authors note that the study was observational, involved a small cohort and lacked a control group. They conclude that larger controlled studies are required to better establish efficacy, longevity and reproducibility of the combined approach.