Findings suggest that PN formulations caused only transient arterial flow disturbances without persistent embolisation or tissue necrosis in an animal model. 

Published in Scientific Reports, the study compared three PN formulations with cross-linked hyaluronic acid (HA) using a rabbit ear artery model. While the higher-viscosity PN formulation (Conjuran) produced the highest rate of temporary arterial occlusion, followed by Rejuran HB Plus, all PN-related flow disturbances resolved spontaneously. No persistent emboli were detected after 24 hours, and there was no clinical evidence of ischaemia, tissue necrosis or vascular injury after seven days. 

By contrast, cross-linked HA produced persistent intravascular emboli and extensive tissue necrosis, highlighting important differences in vascular behaviour between the two classes of injectable. 

The authors conclude that PN injectables demonstrated favourable intravascular behaviour in this preclinical model. However, they emphasise that further research is needed to understand the underlying mechanisms and determine whether these findings translate to human clinical practice.