Published in Advances in Dermatology and Allergology, the study found that combination therapy achieved a 47.3% reduction in ECCA scar scores, compared with 35.9% for fractional CO₂ laser alone. Improvements were also greater across all scar subtypes, including ice-pick scars (68% vs. 42%), boxcar scars (76% vs. 50%) and rolling scars (72% vs. 48%). 

Patients receiving regenerative adjunctive therapy experienced fewer adverse effects, with lower rates of post-inflammatory hyperpigmentation (10% vs. 24%) and prolonged erythema (14% vs. 30%). They also required fewer treatment sessions (1.8 vs. 2.3), reported higher satisfaction (90% vs. 70%) and were more likely to continue improving three months after treatment (92% vs. 76%). 

The authors conclude that combining regenerative biologics with fractional CO₂ laser may enhance clinical outcomes while reducing downtime, although larger studies are needed to establish long-term efficacy and determine the relative benefits of PN and exosome-mimetic therapies.